Thomas Byrne may refer to:

• Thomas Byrne (VC) (1866–1944), Irish Victoria Cross recipient
• Thomas R. Byrne (1923–2009), former U.S. politician, former mayor of Saint Paul, Minnesota
• Thomas Ryan Byrne (1923-2014), former U.S. career diplomat, ambassador
• Thomas Byrne (actor) (born 1997), English actor
• Thomas Byrne (Meath politician) (born 1977), Irish Fianna Fáil politician representing Meath East
• Thomas Byrne (Dublin politician) (1917–1978), Irish independent politician represented Dublin North West from 1951–1961
• Thomas Sebastian Byrne (1841–1923), American Roman Catholic clergyman
• Thomas Byrne, co-founder of SA Hauts-Fourneaux de Rodange